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Title: Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent
Authors: Zheng, J.
Liu, X.
Yuan, Q. 
Shin, Y.-J.
Sun, D.
Lu, Y. 
Issue Date: 2010
Citation: Zheng, J., Liu, X., Yuan, Q., Shin, Y.-J., Sun, D., Lu, Y. (2010). Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent. Organic and Biomolecular Chemistry 8 (6) : 1293-1295. ScholarBank@NUS Repository.
Abstract: Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy. © 2010 The Royal Society of Chemistry.
Source Title: Organic and Biomolecular Chemistry
ISSN: 14770520
DOI: 10.1039/b926217b
Appears in Collections:Staff Publications

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