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https://doi.org/10.1039/b926217b
| Title: | Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent | Authors: | Zheng, J. Liu, X. Yuan, Q. Shin, Y.-J. Sun, D. Lu, Y. |
Issue Date: | 2010 | Citation: | Zheng, J., Liu, X., Yuan, Q., Shin, Y.-J., Sun, D., Lu, Y. (2010). Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent. Organic and Biomolecular Chemistry 8 (6) : 1293-1295. ScholarBank@NUS Repository. https://doi.org/10.1039/b926217b | Abstract: | Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy. © 2010 The Royal Society of Chemistry. | Source Title: | Organic and Biomolecular Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/77287 | ISSN: | 14770520 | DOI: | 10.1039/b926217b |
| Appears in Collections: | Staff Publications |
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