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|Title:||Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent|
|Citation:||Zheng, J., Liu, X., Yuan, Q., Shin, Y.-J., Sun, D., Lu, Y. (2010). Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent. Organic and Biomolecular Chemistry 8 (6) : 1293-1295. ScholarBank@NUS Repository. https://doi.org/10.1039/b926217b|
|Abstract:||Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy. © 2010 The Royal Society of Chemistry.|
|Source Title:||Organic and Biomolecular Chemistry|
|Appears in Collections:||Staff Publications|
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