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|Title:||Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities||Authors:||Na, Z.
|Issue Date:||25-Jul-2012||Citation:||Na, Z., Li, L., Uttamchandani, M., Yao, S.Q. (2012-07-25). Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities. Chemical Communications 48 (58) : 7304-7306. ScholarBank@NUS Repository. https://doi.org/10.1039/c2cc33476c||Abstract:||A microarray immobilized with 105 aldehyde-containing small molecules was screened against mammalian cell lysates over-expressing cathepsin L to identify two potent inhibitors, which were subsequently converted into cell-permeable probes capable of live-cell imaging of endogenous cysteinyl cathepsin activities by two-photon fluorescence microscopy. © 2012 The Royal Society of Chemistry.||Source Title:||Chemical Communications||URI:||http://scholarbank.nus.edu.sg/handle/10635/76489||ISSN:||13597345||DOI:||10.1039/c2cc33476c|
|Appears in Collections:||Staff Publications|
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