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https://doi.org/10.1002/chem.201003761
| Title: | Fluorinated aromatic ketones as nucleophiles in the asymmetric organocatalytic formation of C-C and C-N bonds: A facile route to the construction of fluorinated quaternary stereogenic centers | Authors: | Zhao, Y. Pan, Y. Liu, H. Yang, Y. Jiang, Z. Tan, C.-H. |
Keywords: | amination fluorine Mannich reaction organocatalysis quaternary stereogenic center |
Issue Date: | 21-Mar-2011 | Citation: | Zhao, Y., Pan, Y., Liu, H., Yang, Y., Jiang, Z., Tan, C.-H. (2011-03-21). Fluorinated aromatic ketones as nucleophiles in the asymmetric organocatalytic formation of C-C and C-N bonds: A facile route to the construction of fluorinated quaternary stereogenic centers. Chemistry - A European Journal 17 (13) : 3571-3574. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201003761 | Abstract: | Highly enantioselective Mannich and α-amination reactions have been successfully developed using α-fluorinated aromatic ketones as fluorocarbon nucleophiles in the presence of a bicyclic chiral guanidine (see scheme; Ms=methanesulfonyl). This method is a simple and efficient approach to the construction of fluorinated quaternary stereogenic centers. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Chemistry - A European Journal | URI: | http://scholarbank.nus.edu.sg/handle/10635/76199 | ISSN: | 09476539 | DOI: | 10.1002/chem.201003761 |
| Appears in Collections: | Staff Publications |
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