Please use this identifier to cite or link to this item: https://doi.org/10.1002/chem.201003761
Title: Fluorinated aromatic ketones as nucleophiles in the asymmetric organocatalytic formation of C-C and C-N bonds: A facile route to the construction of fluorinated quaternary stereogenic centers
Authors: Zhao, Y. 
Pan, Y.
Liu, H.
Yang, Y.
Jiang, Z.
Tan, C.-H. 
Keywords: amination
fluorine
Mannich reaction
organocatalysis
quaternary stereogenic center
Issue Date: 21-Mar-2011
Citation: Zhao, Y., Pan, Y., Liu, H., Yang, Y., Jiang, Z., Tan, C.-H. (2011-03-21). Fluorinated aromatic ketones as nucleophiles in the asymmetric organocatalytic formation of C-C and C-N bonds: A facile route to the construction of fluorinated quaternary stereogenic centers. Chemistry - A European Journal 17 (13) : 3571-3574. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201003761
Abstract: Highly enantioselective Mannich and α-amination reactions have been successfully developed using α-fluorinated aromatic ketones as fluorocarbon nucleophiles in the presence of a bicyclic chiral guanidine (see scheme; Ms=methanesulfonyl). This method is a simple and efficient approach to the construction of fluorinated quaternary stereogenic centers. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Chemistry - A European Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/76199
ISSN: 09476539
DOI: 10.1002/chem.201003761
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