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https://doi.org/10.1002/anie.201208285
| Title: | Chiral phosphine catalyzed asymmetric michael addition of oxindoles | Authors: | Zhong, F. Dou, X. Han, X. Yao, W. Zhu, Q. Meng, Y. Lu, Y. |
Keywords: | alkenes amino acids bifunctional phosphines Michael addition oxindoles |
Issue Date: | 14-Jan-2013 | Citation: | Zhong, F., Dou, X., Han, X., Yao, W., Zhu, Q., Meng, Y., Lu, Y. (2013-01-14). Chiral phosphine catalyzed asymmetric michael addition of oxindoles. Angewandte Chemie - International Edition 52 (3) : 943-947. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201208285 | Abstract: | Bifunctional phosphines derived from amino acids mediate the asymmetric Michael addition of 3-substituted oxindoles to activated alkenes (see scheme). Biologically relevant chiral 3,3-disubstituted oxindoles were thus prepared in high yields and with excellent enantioselectivities from 3-aryl- and 3-alkyl-substituted oxindoles and various activated alkenes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/75753 | ISSN: | 14337851 | DOI: | 10.1002/anie.201208285 |
| Appears in Collections: | Staff Publications |
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