Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201208285
Title: Chiral phosphine catalyzed asymmetric michael addition of oxindoles
Authors: Zhong, F.
Dou, X.
Han, X.
Yao, W.
Zhu, Q.
Meng, Y.
Lu, Y. 
Keywords: alkenes
amino acids
bifunctional phosphines
Michael addition
oxindoles
Issue Date: 14-Jan-2013
Citation: Zhong, F., Dou, X., Han, X., Yao, W., Zhu, Q., Meng, Y., Lu, Y. (2013-01-14). Chiral phosphine catalyzed asymmetric michael addition of oxindoles. Angewandte Chemie - International Edition 52 (3) : 943-947. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201208285
Abstract: Bifunctional phosphines derived from amino acids mediate the asymmetric Michael addition of 3-substituted oxindoles to activated alkenes (see scheme). Biologically relevant chiral 3,3-disubstituted oxindoles were thus prepared in high yields and with excellent enantioselectivities from 3-aryl- and 3-alkyl-substituted oxindoles and various activated alkenes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/75753
ISSN: 14337851
DOI: 10.1002/anie.201208285
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