Please use this identifier to cite or link to this item:
https://doi.org/10.1021/ja1048972
| Title: | Asymmetric bromolactonization using amino-thiocarbamate catalyst | Authors: | Zhou, L. Tan, C.K. Jiang, X. Chen, F. Yeung, Y.-Y. |
Issue Date: | 10-Nov-2010 | Citation: | Zhou, L., Tan, C.K., Jiang, X., Chen, F., Yeung, Y.-Y. (2010-11-10). Asymmetric bromolactonization using amino-thiocarbamate catalyst. Journal of the American Chemical Society 132 (44) : 15474-15476. ScholarBank@NUS Repository. https://doi.org/10.1021/ja1048972 | Abstract: | A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists. © 2010 American Chemical Society. | Source Title: | Journal of the American Chemical Society | URI: | http://scholarbank.nus.edu.sg/handle/10635/75615 | ISSN: | 00027863 | DOI: | 10.1021/ja1048972 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.