Please use this identifier to cite or link to this item: https://doi.org/10.1021/ja1048972
Title: Asymmetric bromolactonization using amino-thiocarbamate catalyst
Authors: Zhou, L.
Tan, C.K.
Jiang, X.
Chen, F.
Yeung, Y.-Y. 
Issue Date: 10-Nov-2010
Citation: Zhou, L., Tan, C.K., Jiang, X., Chen, F., Yeung, Y.-Y. (2010-11-10). Asymmetric bromolactonization using amino-thiocarbamate catalyst. Journal of the American Chemical Society 132 (44) : 15474-15476. ScholarBank@NUS Repository. https://doi.org/10.1021/ja1048972
Abstract: A novel amino-thiocarbamate-catalyzed bromolactonization of unsaturated carboxylic acids has been developed. The scope of the reaction is evidenced by 22 examples of γ-lactones with up to 99% yield and 93% ee. The protocol was applied in the enantioselective synthesis of the key intermediates of VLA-4 antagonists. © 2010 American Chemical Society.
Source Title: Journal of the American Chemical Society
URI: http://scholarbank.nus.edu.sg/handle/10635/75615
ISSN: 00027863
DOI: 10.1021/ja1048972
Appears in Collections:Staff Publications

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