Please use this identifier to cite or link to this item:
|Title:||AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents||Authors:||Zhou, J.
|Issue Date:||16-Jan-2013||Citation:||Zhou, J., Ng, S., Huang, Q., Wu, Y.-T., Li, Z., Yao, S.Q., Shen, H.-M. (2013-01-16). AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents. FEBS Letters 587 (2) : 170-177. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2012.11.018||Abstract:||In this study we aim to elucidate the signaling pathway and biological function of autophagy induced by MNNG, a commonly used DNA alkylating agent. We first observed that MNNG is able to induce necrotic cell death and autophagy in Bax-/- Bak-/- double knockout MEFs. We analyzed the critical role of PARP-1 activation and ATP depletion in MNNG-mediated cell death and autophagy via AMPK activation and mTOR suppression. We provide evidence that suppression of AMPK blocks MNNG-induced autophagy and enhances cell death, suggesting the pro-survival function of autophagy in MNNG-treated cells. Taken together, data from this study reveal a novel mechanism in controlling MNNG-mediated autophagy via AMPK activation downstream of PARP-1 activation and ATP depletion. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.||Source Title:||FEBS Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/75552||ISSN:||00145793||DOI:||10.1016/j.febslet.2012.11.018|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.