Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2012.11.018
Title: AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents
Authors: Zhou, J. 
Ng, S.
Huang, Q. 
Wu, Y.-T.
Li, Z.
Yao, S.Q. 
Shen, H.-M. 
Keywords: Alkylating agent
AMPK
Autophagy
DNA damage
Necrosis
PARP-1
Issue Date: 16-Jan-2013
Citation: Zhou, J., Ng, S., Huang, Q., Wu, Y.-T., Li, Z., Yao, S.Q., Shen, H.-M. (2013-01-16). AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents. FEBS Letters 587 (2) : 170-177. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2012.11.018
Abstract: In this study we aim to elucidate the signaling pathway and biological function of autophagy induced by MNNG, a commonly used DNA alkylating agent. We first observed that MNNG is able to induce necrotic cell death and autophagy in Bax-/- Bak-/- double knockout MEFs. We analyzed the critical role of PARP-1 activation and ATP depletion in MNNG-mediated cell death and autophagy via AMPK activation and mTOR suppression. We provide evidence that suppression of AMPK blocks MNNG-induced autophagy and enhances cell death, suggesting the pro-survival function of autophagy in MNNG-treated cells. Taken together, data from this study reveal a novel mechanism in controlling MNNG-mediated autophagy via AMPK activation downstream of PARP-1 activation and ATP depletion. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/75552
ISSN: 00145793
DOI: 10.1016/j.febslet.2012.11.018
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