Activity-based fluorescent probes that target phosphatases

Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0040-4039(03)00348-4

Title:	Activity-based fluorescent probes that target phosphatases
Authors:	Zhu, Q. Huang, X. Chen, G.Y.J. Yao, S.Q.
Issue Date:	24-Mar-2003
Citation:	Zhu, Q., Huang, X., Chen, G.Y.J., Yao, S.Q. (2003-03-24). Activity-based fluorescent probes that target phosphatases. Tetrahedron Letters 44 (13) : 2669-2672. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(03)00348-4
Abstract:	We have successfully designed and synthesized two fluorescently-labeled, activity-based probes, Probe 1 and Probe 2, which were shown to label protein tyrosine phosphatases specifically, as well as other types of phosphatases. The probes were not reactive towards the other non-phosphatase enzymes tested. These probes may find potential applications in large-scale proteomic experiments whereby subclasses of proteins may be selectively identified. © 2003 Elsevier Science Ltd. All rights reserved.
Source Title:	Tetrahedron Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/75521
ISSN:	00404039
DOI:	10.1016/S0040-4039(03)00348-4
Appears in Collections:	Staff Publications

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