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https://doi.org/10.1002/anie.201205940
| Title: | A switchable two-photon membrane tracer capable of imaging membrane-associated protein tyrosine phosphatase activities | Authors: | Li, L. Shen, X. Xu, Q.-H. Yao, S.Q. |
Keywords: | Bioimaging Fluorescence microscopy Membrane proteins Phosphatases Small-molecule probes |
Issue Date: | 2-Jan-2013 | Citation: | Li, L., Shen, X., Xu, Q.-H., Yao, S.Q. (2013-01-02). A switchable two-photon membrane tracer capable of imaging membrane-associated protein tyrosine phosphatase activities. Angewandte Chemie - International Edition 52 (1) : 424-428. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201205940 | Abstract: | When I look into your cells: A two-photon dye (Flu7) was developed (see scheme), which strongly fluoresces only upon selective binding to the plasma membrane of mammalian cells. Upon addition of a UV- and phosphatase-controlled quencher (Q12), the system exhibits ON/OFF/ON fluorescence switching and can be used to image membrane-associated receptor-like protein tyrosine phosphatase (RPTP) activity. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/75494 | ISSN: | 14337851 | DOI: | 10.1002/anie.201205940 |
| Appears in Collections: | Staff Publications |
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