Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201205940
Title: A switchable two-photon membrane tracer capable of imaging membrane-associated protein tyrosine phosphatase activities
Authors: Li, L. 
Shen, X.
Xu, Q.-H. 
Yao, S.Q. 
Keywords: Bioimaging
Fluorescence microscopy
Membrane proteins
Phosphatases
Small-molecule probes
Issue Date: 2-Jan-2013
Citation: Li, L., Shen, X., Xu, Q.-H., Yao, S.Q. (2013-01-02). A switchable two-photon membrane tracer capable of imaging membrane-associated protein tyrosine phosphatase activities. Angewandte Chemie - International Edition 52 (1) : 424-428. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201205940
Abstract: When I look into your cells: A two-photon dye (Flu7) was developed (see scheme), which strongly fluoresces only upon selective binding to the plasma membrane of mammalian cells. Upon addition of a UV- and phosphatase-controlled quencher (Q12), the system exhibits ON/OFF/ON fluorescence switching and can be used to image membrane-associated receptor-like protein tyrosine phosphatase (RPTP) activity. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/75494
ISSN: 14337851
DOI: 10.1002/anie.201205940
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