Please use this identifier to cite or link to this item:
|Title:||A run-to-run control strategy for polymorphic transformation in pharmaceutical crystallization||Authors:||Hermanto, M.W.
|Issue Date:||2006||Citation:||Hermanto, M.W.,Braatz, R.D.,Chiu, M.-S. (2006). A run-to-run control strategy for polymorphic transformation in pharmaceutical crystallization. Proceedings of the IEEE International Conference on Control Applications : 2121-2126. ScholarBank@NUS Repository. https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776968||Abstract:||Polymorphism is a phenomenon that a substance can have more than one crystal form, each with distinct characteristics. Consequently, controlling polymorphism in drug manufacturing industries are crucial in order to ensure consistent production of the desired polymorph. In this paper, a run-to-run concentration control (C-control) based on iterative learning control is developed. As a case study, a model of polymorphic transformation of L-Glutamic acid from metastable α-form to stable β-form, where the yield of β-form is to be maximized, is used to illustrate the proposed run-to-run C-control and its advantage over the conventional C-control. ©2006 IEEE.||Source Title:||Proceedings of the IEEE International Conference on Control Applications||URI:||http://scholarbank.nus.edu.sg/handle/10635/74461||DOI:||10.1109/CACSD-CCA-ISIC.2006.4776968|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 16, 2019
checked on Jun 14, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.