Please use this identifier to cite or link to this item: https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776968
Title: A run-to-run control strategy for polymorphic transformation in pharmaceutical crystallization
Authors: Hermanto, M.W.
Braatz, R.D.
Chiu, M.-S. 
Issue Date: 2006
Source: Hermanto, M.W.,Braatz, R.D.,Chiu, M.-S. (2006). A run-to-run control strategy for polymorphic transformation in pharmaceutical crystallization. Proceedings of the IEEE International Conference on Control Applications : 2121-2126. ScholarBank@NUS Repository. https://doi.org/10.1109/CACSD-CCA-ISIC.2006.4776968
Abstract: Polymorphism is a phenomenon that a substance can have more than one crystal form, each with distinct characteristics. Consequently, controlling polymorphism in drug manufacturing industries are crucial in order to ensure consistent production of the desired polymorph. In this paper, a run-to-run concentration control (C-control) based on iterative learning control is developed. As a case study, a model of polymorphic transformation of L-Glutamic acid from metastable α-form to stable β-form, where the yield of β-form is to be maximized, is used to illustrate the proposed run-to-run C-control and its advantage over the conventional C-control. ©2006 IEEE.
Source Title: Proceedings of the IEEE International Conference on Control Applications
URI: http://scholarbank.nus.edu.sg/handle/10635/74461
DOI: 10.1109/CACSD-CCA-ISIC.2006.4776968
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