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Title: In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy
Authors: Huang, Z. 
Bergholt, M.S. 
Zheng, W. 
Lin, K. 
Ho, K.Y.
Teh, M.
Yeoh, K.G.
Keywords: Gastric dysplasia
In vivo diagnosis
Narrow-band imaging
Raman endoscopy
Issue Date: May-2010
Citation: Huang, Z., Bergholt, M.S., Zheng, W., Lin, K., Ho, K.Y., Teh, M., Yeoh, K.G. (2010-05). In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy. Journal of Biomedical Optics 15 (3) : -. ScholarBank@NUS Repository.
Abstract: We first report on the implementation of a novel narrowband image-guided Raman endoscopy technique for in vivo diagnosis of gastric dysplasia. High-quality in vivo Raman spectra can be acquired from normal and dysplastic gastric mucosal tissue within 0.5 sec under narrow-band image (NBI) guidance at gastroscopy. Significant differences are observed in in vivo Raman spectra between normal (n=54) and dysplastic (n=18) gastric tissue from 30 gastric patients, particularly in the spectral ranges of 825 to 950, 1000 to 1100, 1250 to 1500, and 1600 to 1800 cm-1, which primarily contain signals related to proteins, nucleic acids, and lipids. The multivariate analysis [i.e., principal components analysis (PCA) and linear discriminant analysis (LDA)], together with the leave-one tissue siteout, cross validation on in vivo gastric Raman spectra yields a diagnostic sensitivity of 94.4% (17/18) and specificity of 96.3% (52/54) for distinction of gastric dysplastic tissue. This study suggests that narrowband image-guided Raman endoscopy associated with PCA-LDA diagnostic algorithms has potential for the noninvasive, in vivo early diagnosis and detection of gastric precancer during clinical gastroscopic examination. © 2010 Society of Photo-Optical Instrumentation Engineers.
Source Title: Journal of Biomedical Optics
ISSN: 10833668
DOI: 10.1117/1.3420115
Appears in Collections:Staff Publications

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