Please use this identifier to cite or link to this item: https://doi.org/10.1117/1.3420115
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dc.titleIn vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy
dc.contributor.authorHuang, Z.
dc.contributor.authorBergholt, M.S.
dc.contributor.authorZheng, W.
dc.contributor.authorLin, K.
dc.contributor.authorHo, K.Y.
dc.contributor.authorTeh, M.
dc.contributor.authorYeoh, K.G.
dc.date.accessioned2014-06-17T09:44:33Z
dc.date.available2014-06-17T09:44:33Z
dc.date.issued2010-05
dc.identifier.citationHuang, Z., Bergholt, M.S., Zheng, W., Lin, K., Ho, K.Y., Teh, M., Yeoh, K.G. (2010-05). In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy. Journal of Biomedical Optics 15 (3) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3420115
dc.identifier.issn10833668
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/67108
dc.description.abstractWe first report on the implementation of a novel narrowband image-guided Raman endoscopy technique for in vivo diagnosis of gastric dysplasia. High-quality in vivo Raman spectra can be acquired from normal and dysplastic gastric mucosal tissue within 0.5 sec under narrow-band image (NBI) guidance at gastroscopy. Significant differences are observed in in vivo Raman spectra between normal (n=54) and dysplastic (n=18) gastric tissue from 30 gastric patients, particularly in the spectral ranges of 825 to 950, 1000 to 1100, 1250 to 1500, and 1600 to 1800 cm-1, which primarily contain signals related to proteins, nucleic acids, and lipids. The multivariate analysis [i.e., principal components analysis (PCA) and linear discriminant analysis (LDA)], together with the leave-one tissue siteout, cross validation on in vivo gastric Raman spectra yields a diagnostic sensitivity of 94.4% (17/18) and specificity of 96.3% (52/54) for distinction of gastric dysplastic tissue. This study suggests that narrowband image-guided Raman endoscopy associated with PCA-LDA diagnostic algorithms has potential for the noninvasive, in vivo early diagnosis and detection of gastric precancer during clinical gastroscopic examination. © 2010 Society of Photo-Optical Instrumentation Engineers.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1117/1.3420115
dc.sourceScopus
dc.subjectGastric dysplasia
dc.subjectGastroscopy
dc.subjectIn vivo diagnosis
dc.subjectNarrow-band imaging
dc.subjectPrecancer
dc.subjectRaman endoscopy
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1117/1.3420115
dc.description.sourcetitleJournal of Biomedical Optics
dc.description.volume15
dc.description.issue3
dc.description.page-
dc.description.codenJBOPF
dc.identifier.isiut000280642900059
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