Please use this identifier to cite or link to this item: https://doi.org/10.1117/1.3420115
Title: In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy
Authors: Huang, Z. 
Bergholt, M.S. 
Zheng, W. 
Lin, K. 
Ho, K.Y.
Teh, M.
Yeoh, K.G.
Keywords: Gastric dysplasia
Gastroscopy
In vivo diagnosis
Narrow-band imaging
Precancer
Raman endoscopy
Issue Date: May-2010
Source: Huang, Z., Bergholt, M.S., Zheng, W., Lin, K., Ho, K.Y., Teh, M., Yeoh, K.G. (2010-05). In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy. Journal of Biomedical Optics 15 (3) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3420115
Abstract: We first report on the implementation of a novel narrowband image-guided Raman endoscopy technique for in vivo diagnosis of gastric dysplasia. High-quality in vivo Raman spectra can be acquired from normal and dysplastic gastric mucosal tissue within 0.5 sec under narrow-band image (NBI) guidance at gastroscopy. Significant differences are observed in in vivo Raman spectra between normal (n=54) and dysplastic (n=18) gastric tissue from 30 gastric patients, particularly in the spectral ranges of 825 to 950, 1000 to 1100, 1250 to 1500, and 1600 to 1800 cm-1, which primarily contain signals related to proteins, nucleic acids, and lipids. The multivariate analysis [i.e., principal components analysis (PCA) and linear discriminant analysis (LDA)], together with the leave-one tissue siteout, cross validation on in vivo gastric Raman spectra yields a diagnostic sensitivity of 94.4% (17/18) and specificity of 96.3% (52/54) for distinction of gastric dysplastic tissue. This study suggests that narrowband image-guided Raman endoscopy associated with PCA-LDA diagnostic algorithms has potential for the noninvasive, in vivo early diagnosis and detection of gastric precancer during clinical gastroscopic examination. © 2010 Society of Photo-Optical Instrumentation Engineers.
Source Title: Journal of Biomedical Optics
URI: http://scholarbank.nus.edu.sg/handle/10635/67108
ISSN: 10833668
DOI: 10.1117/1.3420115
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

62
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

55
checked on Nov 22, 2017

Page view(s)

40
checked on Dec 18, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.