Please use this identifier to cite or link to this item:
|Title:||Identifying synergistically switching pathways for multi-product strain improvement using multiobjective flux balance analysis||Authors:||Selvarasu, S.
A. Karimi, I.
|Keywords:||gene target identification
multiobjective flux balance analysis
|Issue Date:||2007||Citation:||Selvarasu, S.,Lee, D.-Y.,A. Karimi, I. (2007). Identifying synergistically switching pathways for multi-product strain improvement using multiobjective flux balance analysis. Computer Aided Chemical Engineering 24 : 1007-1012. ScholarBank@NUS Repository. https://doi.org/10.1016/S1570-7946(07)80192-1||Abstract:||The current work involves in silico analysis of metabolic network of E. coli, characterizing its pathways for the production of various industrially important metabolites including pyruvate, acetate, lactate, ethanol and various amino acids. Initially, the correlation among the flux distribution profiles for each objective has been investigated by resorting to a novel multiobjective optimization. Subsequently, we identified the genes which are significant for switching the metabolic pathways from one objective to another. Thus, the present analysis allows us to explore synergism among the metabolic pathways for different combinations of multi-products, providing a new insight into the behavior of the biological system. © 2007 Elsevier B.V. All rights reserved.||Source Title:||Computer Aided Chemical Engineering||URI:||http://scholarbank.nus.edu.sg/handle/10635/64054||ISBN:||9780444531575||ISSN:||15707946||DOI:||10.1016/S1570-7946(07)80192-1|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 15, 2019
checked on May 18, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.