Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1570-7946(07)80192-1
Title: Identifying synergistically switching pathways for multi-product strain improvement using multiobjective flux balance analysis
Authors: Selvarasu, S.
Lee, D.-Y. 
A. Karimi, I. 
Keywords: gene target identification
Metabolic engineering
multiobjective flux balance analysis
strain improvement
synergistic pathway
Issue Date: 2007
Source: Selvarasu, S.,Lee, D.-Y.,A. Karimi, I. (2007). Identifying synergistically switching pathways for multi-product strain improvement using multiobjective flux balance analysis. Computer Aided Chemical Engineering 24 : 1007-1012. ScholarBank@NUS Repository. https://doi.org/10.1016/S1570-7946(07)80192-1
Abstract: The current work involves in silico analysis of metabolic network of E. coli, characterizing its pathways for the production of various industrially important metabolites including pyruvate, acetate, lactate, ethanol and various amino acids. Initially, the correlation among the flux distribution profiles for each objective has been investigated by resorting to a novel multiobjective optimization. Subsequently, we identified the genes which are significant for switching the metabolic pathways from one objective to another. Thus, the present analysis allows us to explore synergism among the metabolic pathways for different combinations of multi-products, providing a new insight into the behavior of the biological system. © 2007 Elsevier B.V. All rights reserved.
Source Title: Computer Aided Chemical Engineering
URI: http://scholarbank.nus.edu.sg/handle/10635/64054
ISBN: 9780444531575
ISSN: 15707946
DOI: 10.1016/S1570-7946(07)80192-1
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