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Title: Mass transport and shear stress in a microchannel bioreactor: Numerical simulation and dynamic similarity
Authors: Zeng, Y. 
Lee, T.-S. 
Yu, P. 
Roy, P. 
Low, H.-T. 
Keywords: Cell culture
Microchannel bioreactor
Shear stress
Substrate concentration
Issue Date: Apr-2006
Citation: Zeng, Y., Lee, T.-S., Yu, P., Roy, P., Low, H.-T. (2006-04). Mass transport and shear stress in a microchannel bioreactor: Numerical simulation and dynamic similarity. Journal of Biomechanical Engineering 128 (2) : 185-193. ScholarBank@NUS Repository.
Abstract: Microchannel bioreactors have been used in many studies to manipulate and investigate the fluid microenvironment around cells. In this study, substrate concentrations and shear stresses at the base were computed from a three-dimensional numerical flow-model incorporating mass transport. Combined dimensionless parameters were developed from a simplified analysis. The numerical results of substrate concentration were well correlated by the combined parameters. The generalized results may find applications in design analysis of microchannel bioreactors. The mass transport and shear stress were related in a generalized result. Based on the generalized results and the condition of dynamic similarity, various means to isolate their respective effects on cells were considered. Copyright © 2006 by ASME.
Source Title: Journal of Biomechanical Engineering
ISSN: 01480731
DOI: 10.1115/1.2170118
Appears in Collections:Staff Publications

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