Please use this identifier to cite or link to this item:
Title: One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules
Authors: Leptihn, S.
Guo, L. 
Frecer, V.
Ho, B.
Ding, J.L. 
Wohland, T. 
Keywords: α-helical peptides
Antimicrobial peptides
Biological activity
Nanoparticle conjugate
Peptide antibiotics
Quantum dots
Single molecule detection
Single particle tracking
Structure-function relationship
Issue Date: Jan-2010
Citation: Leptihn, S.,Guo, L.,Frecer, V.,Ho, B.,Ding, J.L.,Wohland, T. (2010-01). One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules. Virulence 1 (1) : 42-44. ScholarBank@NUS Repository.
Abstract: Antimicrobial peptides (AMPs) are a crucial part of the innate immune system of eukaryotes and present a possible alternative to common antibiotics. It is therefore of great importance to understand their modes of action. Using a single-molecule approach in combination with high resolution imaging and biofunctional assays we were able to determine the different steps occurring during the action of the α-helical AMP Sushi 1 during bacterial lysis in spatial and temporal resolution in a biologically relevant context. Furthermore, we comment on the use of Sushi 1 as a template for new peptides to learn more about structurefunction relationship of AMPs. © 2010 Landes Bioscience.
Source Title: Virulence
ISSN: 21505594
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Oct 14, 2021

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.