Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/53068
DC Field | Value | |
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dc.title | One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules | |
dc.contributor.author | Leptihn, S. | |
dc.contributor.author | Guo, L. | |
dc.contributor.author | Frecer, V. | |
dc.contributor.author | Ho, B. | |
dc.contributor.author | Ding, J.L. | |
dc.contributor.author | Wohland, T. | |
dc.date.accessioned | 2014-05-19T02:53:48Z | |
dc.date.available | 2014-05-19T02:53:48Z | |
dc.date.issued | 2010-01 | |
dc.identifier.citation | Leptihn, S., Guo, L., Frecer, V., Ho, B., Ding, J.L., Wohland, T. (2010-01). One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules. Virulence 1 (1) : 42-44. ScholarBank@NUS Repository. | |
dc.identifier.issn | 21505594 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/53068 | |
dc.description.abstract | Antimicrobial peptides (AMPs) are a crucial part of the innate immune system of eukaryotes and present a possible alternative to common antibiotics. It is therefore of great importance to understand their modes of action. Using a single-molecule approach in combination with high resolution imaging and biofunctional assays we were able to determine the different steps occurring during the action of the α-helical AMP Sushi 1 during bacterial lysis in spatial and temporal resolution in a biologically relevant context. Furthermore, we comment on the use of Sushi 1 as a template for new peptides to learn more about structurefunction relationship of AMPs. © 2010 Landes Bioscience. | |
dc.source | Scopus | |
dc.subject | α-helical peptides | |
dc.subject | Amphipathicity | |
dc.subject | Antimicrobial peptides | |
dc.subject | Biological activity | |
dc.subject | Endotoxin | |
dc.subject | Lipopolysaccharide | |
dc.subject | Nanoparticle conjugate | |
dc.subject | Peptide antibiotics | |
dc.subject | Quantum dots | |
dc.subject | Single molecule detection | |
dc.subject | Single particle tracking | |
dc.subject | Structure-function relationship | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.sourcetitle | Virulence | |
dc.description.volume | 1 | |
dc.description.issue | 1 | |
dc.description.page | 42-44 | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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