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|Title:||One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules|
Single molecule detection
Single particle tracking
|Source:||Leptihn, S.,Guo, L.,Frecer, V.,Ho, B.,Ding, J.L.,Wohland, T. (2010-01). One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules. Virulence 1 (1) : 42-44. ScholarBank@NUS Repository.|
|Abstract:||Antimicrobial peptides (AMPs) are a crucial part of the innate immune system of eukaryotes and present a possible alternative to common antibiotics. It is therefore of great importance to understand their modes of action. Using a single-molecule approach in combination with high resolution imaging and biofunctional assays we were able to determine the different steps occurring during the action of the α-helical AMP Sushi 1 during bacterial lysis in spatial and temporal resolution in a biologically relevant context. Furthermore, we comment on the use of Sushi 1 as a template for new peptides to learn more about structurefunction relationship of AMPs. © 2010 Landes Bioscience.|
|Appears in Collections:||Staff Publications|
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