Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/53068
Title: One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules
Authors: Leptihn, S.
Guo, L. 
Frecer, V.
Ho, B.
Ding, J.L. 
Wohland, T. 
Keywords: α-helical peptides
Amphipathicity
Antimicrobial peptides
Biological activity
Endotoxin
Lipopolysaccharide
Nanoparticle conjugate
Peptide antibiotics
Quantum dots
Single molecule detection
Single particle tracking
Structure-function relationship
Issue Date: Jan-2010
Source: Leptihn, S.,Guo, L.,Frecer, V.,Ho, B.,Ding, J.L.,Wohland, T. (2010-01). One step at a time: Action mechanism of Sushi 1 antimicrobial peptide and derived molecules. Virulence 1 (1) : 42-44. ScholarBank@NUS Repository.
Abstract: Antimicrobial peptides (AMPs) are a crucial part of the innate immune system of eukaryotes and present a possible alternative to common antibiotics. It is therefore of great importance to understand their modes of action. Using a single-molecule approach in combination with high resolution imaging and biofunctional assays we were able to determine the different steps occurring during the action of the α-helical AMP Sushi 1 during bacterial lysis in spatial and temporal resolution in a biologically relevant context. Furthermore, we comment on the use of Sushi 1 as a template for new peptides to learn more about structurefunction relationship of AMPs. © 2010 Landes Bioscience.
Source Title: Virulence
URI: http://scholarbank.nus.edu.sg/handle/10635/53068
ISSN: 21505594
Appears in Collections:Staff Publications

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