Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0056668
Title: Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases
Authors: Ung, C.Y. 
Lam, S.H. 
Zhang, X.
Li, H.
Zhang, L. 
Li, B. 
Gong, Z. 
Issue Date: 14-Feb-2013
Citation: Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Zhang, L., Li, B., Gong, Z. (2013-02-14). Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases. PLoS ONE 8 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0056668
Abstract: The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcriptomic data from human pathological studies were analysed for the responses of male- and female-biased genes. Our analyses revealed obvious inverted expression profiles of sex-biased genes, where affected males tended to up-regulate genes of female-biased expression and down-regulate genes of male-biased expression, and vice versa in affected females, in a broad range of toxico-pathological conditions. Intriguingly, the extent of these inverted profiles correlated well to the susceptibility or severity of a given toxico-pathological state, suggesting that inverted expression profiles of sex-biased genes observed in this study can be used as important indicators to assess biological disorders. © 2013 Ung et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/53002
ISSN: 19326203
DOI: 10.1371/journal.pone.0056668
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