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|Title:||Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding||Authors:||Fawzy, A.S.
|Issue Date:||2012||Citation:||Fawzy, A.S., Nitisusanta, L.I., Iqbal, K., Daood, U., Beng, L.T., Neo, J. (2012). Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding. Journal of the Mechanical Behavior of Biomedical Materials 17 : 278-289. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jmbbm.2012.09.008||Abstract:||Previous studies have suggested different approaches to modify dentin collagen for potential improvement in bonding to dentin. Here, we are proposing a new approach to reinforce dentin collagen fibrils network by chitosan as a reinforcement phase and UVA-activated riboflavin as crosslinking agent within clinically acceptable time-frame as potential substrate for bonding. The effect of modifying demineralized dentin substrates with chitosan/riboflavin, with a gradual increase in chitosan content, was investigated by SEM, nano-indentation, conventional-mechanical testing and hydroxyproline (HYP) release at collagenolytic and/or hydrolytic challenges. The resin/dentin interface morphology, immediate bond strength and short-term bond durability were also investigated using etch-and-rinse dentin adhesive. Modification with chitosan/riboflavin increased the mechanical properties, enhanced the mechanical stability of demineralized dentin substrates against hydrolytic and/or collagenolytic degradation challenges and decreased HYP release with collagenase exposure. When chitosan was added to riboflavin at 20% v/v ratio, significant improvement in bond strength at 24 h and 6 months in distilled water was found indicating the positive dual effect on bonding to dentin. With the gradual increase in chitosan content, obliteration of interfibrillar-spaces that might adversely affect bonding to dentin was found. Although it has a synergetic effect, chitosan content is crucial for any subsequent application in adhesive dentistry. © 2012 Elsevier Ltd.||Source Title:||Journal of the Mechanical Behavior of Biomedical Materials||URI:||http://scholarbank.nus.edu.sg/handle/10635/47133||ISSN:||17516161||DOI:||10.1016/j.jmbbm.2012.09.008|
|Appears in Collections:||Staff Publications|
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