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Title: Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding
Authors: Fawzy, A.S. 
Nitisusanta, L.I.
Iqbal, K.
Daood, U.
Beng, L.T.
Neo, J. 
Keywords: Biodegradation
Dentin bonding
Issue Date: 2012
Citation: Fawzy, A.S., Nitisusanta, L.I., Iqbal, K., Daood, U., Beng, L.T., Neo, J. (2012). Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding. Journal of the Mechanical Behavior of Biomedical Materials 17 : 278-289. ScholarBank@NUS Repository.
Abstract: Previous studies have suggested different approaches to modify dentin collagen for potential improvement in bonding to dentin. Here, we are proposing a new approach to reinforce dentin collagen fibrils network by chitosan as a reinforcement phase and UVA-activated riboflavin as crosslinking agent within clinically acceptable time-frame as potential substrate for bonding. The effect of modifying demineralized dentin substrates with chitosan/riboflavin, with a gradual increase in chitosan content, was investigated by SEM, nano-indentation, conventional-mechanical testing and hydroxyproline (HYP) release at collagenolytic and/or hydrolytic challenges. The resin/dentin interface morphology, immediate bond strength and short-term bond durability were also investigated using etch-and-rinse dentin adhesive. Modification with chitosan/riboflavin increased the mechanical properties, enhanced the mechanical stability of demineralized dentin substrates against hydrolytic and/or collagenolytic degradation challenges and decreased HYP release with collagenase exposure. When chitosan was added to riboflavin at 20% v/v ratio, significant improvement in bond strength at 24 h and 6 months in distilled water was found indicating the positive dual effect on bonding to dentin. With the gradual increase in chitosan content, obliteration of interfibrillar-spaces that might adversely affect bonding to dentin was found. Although it has a synergetic effect, chitosan content is crucial for any subsequent application in adhesive dentistry. © 2012 Elsevier Ltd.
Source Title: Journal of the Mechanical Behavior of Biomedical Materials
ISSN: 17516161
DOI: 10.1016/j.jmbbm.2012.09.008
Appears in Collections:Staff Publications

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