Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jmbbm.2012.09.008
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dc.titleChitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding
dc.contributor.authorFawzy, A.S.
dc.contributor.authorNitisusanta, L.I.
dc.contributor.authorIqbal, K.
dc.contributor.authorDaood, U.
dc.contributor.authorBeng, L.T.
dc.contributor.authorNeo, J.
dc.date.accessioned2013-10-16T07:23:36Z
dc.date.available2013-10-16T07:23:36Z
dc.date.issued2012
dc.identifier.citationFawzy, A.S., Nitisusanta, L.I., Iqbal, K., Daood, U., Beng, L.T., Neo, J. (2012). Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding. Journal of the Mechanical Behavior of Biomedical Materials 17 : 278-289. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jmbbm.2012.09.008
dc.identifier.issn17516161
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/47133
dc.description.abstractPrevious studies have suggested different approaches to modify dentin collagen for potential improvement in bonding to dentin. Here, we are proposing a new approach to reinforce dentin collagen fibrils network by chitosan as a reinforcement phase and UVA-activated riboflavin as crosslinking agent within clinically acceptable time-frame as potential substrate for bonding. The effect of modifying demineralized dentin substrates with chitosan/riboflavin, with a gradual increase in chitosan content, was investigated by SEM, nano-indentation, conventional-mechanical testing and hydroxyproline (HYP) release at collagenolytic and/or hydrolytic challenges. The resin/dentin interface morphology, immediate bond strength and short-term bond durability were also investigated using etch-and-rinse dentin adhesive. Modification with chitosan/riboflavin increased the mechanical properties, enhanced the mechanical stability of demineralized dentin substrates against hydrolytic and/or collagenolytic degradation challenges and decreased HYP release with collagenase exposure. When chitosan was added to riboflavin at 20% v/v ratio, significant improvement in bond strength at 24 h and 6 months in distilled water was found indicating the positive dual effect on bonding to dentin. With the gradual increase in chitosan content, obliteration of interfibrillar-spaces that might adversely affect bonding to dentin was found. Although it has a synergetic effect, chitosan content is crucial for any subsequent application in adhesive dentistry. © 2012 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jmbbm.2012.09.008
dc.sourceScopus
dc.subjectBiodegradation
dc.subjectChitosan
dc.subjectCollagen
dc.subjectDentin bonding
dc.subjectRiboflavin
dc.typeArticle
dc.contributor.departmentDENTISTRY
dc.description.doi10.1016/j.jmbbm.2012.09.008
dc.description.sourcetitleJournal of the Mechanical Behavior of Biomedical Materials
dc.description.volume17
dc.description.page278-289
dc.identifier.isiut000313230400025
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