Please use this identifier to cite or link to this item:
|Title:||Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding|
|Authors:||Fawzy, A.S. |
|Citation:||Fawzy, A.S., Nitisusanta, L.I., Iqbal, K., Daood, U., Beng, L.T., Neo, J. (2012). Chitosan/Riboflavin-modified demineralized dentin as a potential substrate for bonding. Journal of the Mechanical Behavior of Biomedical Materials 17 : 278-289. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jmbbm.2012.09.008|
|Abstract:||Previous studies have suggested different approaches to modify dentin collagen for potential improvement in bonding to dentin. Here, we are proposing a new approach to reinforce dentin collagen fibrils network by chitosan as a reinforcement phase and UVA-activated riboflavin as crosslinking agent within clinically acceptable time-frame as potential substrate for bonding. The effect of modifying demineralized dentin substrates with chitosan/riboflavin, with a gradual increase in chitosan content, was investigated by SEM, nano-indentation, conventional-mechanical testing and hydroxyproline (HYP) release at collagenolytic and/or hydrolytic challenges. The resin/dentin interface morphology, immediate bond strength and short-term bond durability were also investigated using etch-and-rinse dentin adhesive. Modification with chitosan/riboflavin increased the mechanical properties, enhanced the mechanical stability of demineralized dentin substrates against hydrolytic and/or collagenolytic degradation challenges and decreased HYP release with collagenase exposure. When chitosan was added to riboflavin at 20% v/v ratio, significant improvement in bond strength at 24 h and 6 months in distilled water was found indicating the positive dual effect on bonding to dentin. With the gradual increase in chitosan content, obliteration of interfibrillar-spaces that might adversely affect bonding to dentin was found. Although it has a synergetic effect, chitosan content is crucial for any subsequent application in adhesive dentistry. © 2012 Elsevier Ltd.|
|Source Title:||Journal of the Mechanical Behavior of Biomedical Materials|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 8, 2018
WEB OF SCIENCETM
checked on Jul 31, 2018
checked on Jul 27, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.