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Title: A post-processing method for optimizing synthesis strategy for oligonucleotide microarrays
Authors: Ning, K.
Choi, K.P. 
Leong, H.W. 
Zhang, L. 
Issue Date: 2005
Citation: Ning, K., Choi, K.P., Leong, H.W., Zhang, L. (2005). A post-processing method for optimizing synthesis strategy for oligonucleotide microarrays. Nucleic Acids Research 33 (17) : 1-6. ScholarBank@NUS Repository.
Abstract: The broad applicability of gene expression profiling to genomic analyses has generated huge demand for mass production of microarrays and hence for improving the cost effectiveness of microarray fabrication. We developed a post-processing method for deriving a good synthesis strategy. In this paper, we assessed all the known efficient methods and our post-processing method for reducing the number of synthesis cycles for manufacturing a DNA-chip of a given set of oligos. Our experimental results on both simulated and 52 real datasets show that no single method consistently gives the best synthesis strategy, and post-processing an existing strategy is necessary as it often reduces the number of synthesis cycles further. © The Author 2005. Published by Oxford University Press. All rights reserved.
Source Title: Nucleic Acids Research
ISSN: 03051048
DOI: 10.1093/nar/gni147
Appears in Collections:Staff Publications

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