Please use this identifier to cite or link to this item:
|Title:||Fractal analysis of retinal microvasculature and coronary heart disease mortality||Authors:||Liew, G.
|Keywords:||Blue Mountains Eye Study
Coronary heart disease
|Issue Date:||2011||Citation:||Liew, G., Mitchell, P., Rochtchina, E., Wong, T.Y., Hsu, W., Lee, M.L., Wainwright, A., Wang, J.J. (2011). Fractal analysis of retinal microvasculature and coronary heart disease mortality. European Heart Journal 32 (4) : 422-429. ScholarBank@NUS Repository. https://doi.org/10.1093/eurheartj/ehq431||Abstract:||Aim: Fractal analysis provides a global assessment of vascular network architecture. We examined the relationship of retinal vascular fractal dimension (D f) with coronary heart disease (CHD) mortality. Methods and results: We examined the relationship of D f with 14-year CHD mortality in a prospective, population-based cohort of 3303 participants aged 49 years or older. D f was measured from digitized fundus photographs using computer-automated methods; CHD mortality was documented from Australian National Death Index records. Mean D f in this population was 1.441 (standard deviation, 0.024). Over 14 years, there were 468 (14.2%) CHD deaths. Participants with suboptimal D f (lowest and highest quartiles) had 50% higher 14-year CHD mortality than those with optimal D f (middle quartiles), after adjusting for age, blood pressure, and other risk factors. Among participants aged ≤70 years, suboptimal D f was associated with a nearly two-fold higher risk of CHD mortality [adjusted hazard ratio (HR) 1.89, 95% confidence interval (CI), 1.25, 2.84 for the lowest quartile and HR 1.87, CI 1.30, 2.69 for the highest quartile, compared with middle quartiles]. Conclusions: D f is a novel means of quantifying microvascular branching that independently predicted 14-year CHD mortality. These findings suggest that suboptimal microvascular branching may play a role in development of clinical cardiovascular disease. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010.||Source Title:||European Heart Journal||URI:||http://scholarbank.nus.edu.sg/handle/10635/43082||ISSN:||0195668X||DOI:||10.1093/eurheartj/ehq431|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on May 29, 2020
WEB OF SCIENCETM
checked on May 29, 2020
checked on Jun 1, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.