Please use this identifier to cite or link to this item: https://doi.org/10.1093/eurheartj/ehq431
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dc.titleFractal analysis of retinal microvasculature and coronary heart disease mortality
dc.contributor.authorLiew, G.
dc.contributor.authorMitchell, P.
dc.contributor.authorRochtchina, E.
dc.contributor.authorWong, T.Y.
dc.contributor.authorHsu, W.
dc.contributor.authorLee, M.L.
dc.contributor.authorWainwright, A.
dc.contributor.authorWang, J.J.
dc.date.accessioned2013-07-23T09:24:28Z
dc.date.available2013-07-23T09:24:28Z
dc.date.issued2011
dc.identifier.citationLiew, G., Mitchell, P., Rochtchina, E., Wong, T.Y., Hsu, W., Lee, M.L., Wainwright, A., Wang, J.J. (2011). Fractal analysis of retinal microvasculature and coronary heart disease mortality. European Heart Journal 32 (4) : 422-429. ScholarBank@NUS Repository. https://doi.org/10.1093/eurheartj/ehq431
dc.identifier.issn0195668X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/43082
dc.description.abstractAim: Fractal analysis provides a global assessment of vascular network architecture. We examined the relationship of retinal vascular fractal dimension (D f) with coronary heart disease (CHD) mortality. Methods and results: We examined the relationship of D f with 14-year CHD mortality in a prospective, population-based cohort of 3303 participants aged 49 years or older. D f was measured from digitized fundus photographs using computer-automated methods; CHD mortality was documented from Australian National Death Index records. Mean D f in this population was 1.441 (standard deviation, 0.024). Over 14 years, there were 468 (14.2%) CHD deaths. Participants with suboptimal D f (lowest and highest quartiles) had 50% higher 14-year CHD mortality than those with optimal D f (middle quartiles), after adjusting for age, blood pressure, and other risk factors. Among participants aged ≤70 years, suboptimal D f was associated with a nearly two-fold higher risk of CHD mortality [adjusted hazard ratio (HR) 1.89, 95% confidence interval (CI), 1.25, 2.84 for the lowest quartile and HR 1.87, CI 1.30, 2.69 for the highest quartile, compared with middle quartiles]. Conclusions: D f is a novel means of quantifying microvascular branching that independently predicted 14-year CHD mortality. These findings suggest that suboptimal microvascular branching may play a role in development of clinical cardiovascular disease. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1093/eurheartj/ehq431
dc.sourceScopus
dc.subjectBlue Mountains Eye Study
dc.subjectCoronary heart disease
dc.subjectFractals
dc.subjectMicrocirculation
dc.subjectMortality
dc.subjectRetinal microcirculation
dc.typeArticle
dc.contributor.departmentCOMPUTER SCIENCE
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1093/eurheartj/ehq431
dc.description.sourcetitleEuropean Heart Journal
dc.description.volume32
dc.description.issue4
dc.description.page422-429
dc.description.codenEHJOD
dc.identifier.isiut000287496500011
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