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Title: A new molecular variant of luteinizing hormone associated with female infertility
Authors: Liao, W.-X. 
Roy, A.C. 
Chan, C. 
Arulkumaran, S. 
Ratnam, S.S. 
Keywords: Endometriosis
Female infertility
LH β-subunit
Missense mutation
Issue Date: 1998
Citation: Liao, W.-X., Roy, A.C., Chan, C., Arulkumaran, S., Ratnam, S.S. (1998). A new molecular variant of luteinizing hormone associated with female infertility. Fertility and Sterility 69 (1) : 102-106. ScholarBank@NUS Repository.
Abstract: Objective: To investigate whether the newly described G1502 to A1502 mutation in exon 3 of the LH β-subunit gene, causing the amino acid substitution of Ser102 for Gly102, is related to female infertility. Design: Screening of fertile and infertile women for the G1502 to A1502 mutation in the LH β-subunit gene. Setting: Clinics and laboratories of the National University Hospital obstetrics and gynecology department, Singapore. Patient(s): Two hundred twelve healthy fertile women; 40 infertile women with menstrual disorders, polycystic ovary syndrome, and endometriosis; and 12 women with idiopathic infertility. Intervention(s): Exon 3 of the LH β-subunit gene was analyzed using polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), and PCR-mediated direct DNA sequencing. Main Outcome Measure(s): The PCR products of patients were analyzed by RFLP, and the results were compared with those of fertile controls. DNA sequencing radiographs were compared between two mutation-bearing patients and four controls. Result(s): The mutation was identified in only two infertile women with endometriosis; other women studied were found to be negative for this mutation. Conclusion(s): The missense mutation in the LH β-subunit gene may be implicated in female infertility, possibly endometriosis-associated infertility in some women.
Source Title: Fertility and Sterility
ISSN: 00150282
DOI: 10.1016/S0015-0282(97)00445-7
Appears in Collections:Staff Publications

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