Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0015-0282(97)00445-7
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dc.titleA new molecular variant of luteinizing hormone associated with female infertility
dc.contributor.authorLiao, W.-X.
dc.contributor.authorRoy, A.C.
dc.contributor.authorChan, C.
dc.contributor.authorArulkumaran, S.
dc.contributor.authorRatnam, S.S.
dc.date.accessioned2013-04-10T02:59:05Z
dc.date.available2013-04-10T02:59:05Z
dc.date.issued1998
dc.identifier.citationLiao, W.-X., Roy, A.C., Chan, C., Arulkumaran, S., Ratnam, S.S. (1998). A new molecular variant of luteinizing hormone associated with female infertility. Fertility and Sterility 69 (1) : 102-106. ScholarBank@NUS Repository. https://doi.org/10.1016/S0015-0282(97)00445-7
dc.identifier.issn00150282
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/36934
dc.description.abstractObjective: To investigate whether the newly described G1502 to A1502 mutation in exon 3 of the LH β-subunit gene, causing the amino acid substitution of Ser102 for Gly102, is related to female infertility. Design: Screening of fertile and infertile women for the G1502 to A1502 mutation in the LH β-subunit gene. Setting: Clinics and laboratories of the National University Hospital obstetrics and gynecology department, Singapore. Patient(s): Two hundred twelve healthy fertile women; 40 infertile women with menstrual disorders, polycystic ovary syndrome, and endometriosis; and 12 women with idiopathic infertility. Intervention(s): Exon 3 of the LH β-subunit gene was analyzed using polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), and PCR-mediated direct DNA sequencing. Main Outcome Measure(s): The PCR products of patients were analyzed by RFLP, and the results were compared with those of fertile controls. DNA sequencing radiographs were compared between two mutation-bearing patients and four controls. Result(s): The mutation was identified in only two infertile women with endometriosis; other women studied were found to be negative for this mutation. Conclusion(s): The missense mutation in the LH β-subunit gene may be implicated in female infertility, possibly endometriosis-associated infertility in some women.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0015-0282(97)00445-7
dc.sourceScopus
dc.subjectEndometriosis
dc.subjectFemale infertility
dc.subjectLH β-subunit
dc.subjectMissense mutation
dc.subjectPCR
dc.subjectRFLP
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.description.doi10.1016/S0015-0282(97)00445-7
dc.description.sourcetitleFertility and Sterility
dc.description.volume69
dc.description.issue1
dc.description.page102-106
dc.description.codenFESTA
dc.identifier.isiut000071673300020
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