Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0015-0282(97)00445-7
DC Field | Value | |
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dc.title | A new molecular variant of luteinizing hormone associated with female infertility | |
dc.contributor.author | Liao, W.-X. | |
dc.contributor.author | Roy, A.C. | |
dc.contributor.author | Chan, C. | |
dc.contributor.author | Arulkumaran, S. | |
dc.contributor.author | Ratnam, S.S. | |
dc.date.accessioned | 2013-04-10T02:59:05Z | |
dc.date.available | 2013-04-10T02:59:05Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Liao, W.-X., Roy, A.C., Chan, C., Arulkumaran, S., Ratnam, S.S. (1998). A new molecular variant of luteinizing hormone associated with female infertility. Fertility and Sterility 69 (1) : 102-106. ScholarBank@NUS Repository. https://doi.org/10.1016/S0015-0282(97)00445-7 | |
dc.identifier.issn | 00150282 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/36934 | |
dc.description.abstract | Objective: To investigate whether the newly described G1502 to A1502 mutation in exon 3 of the LH β-subunit gene, causing the amino acid substitution of Ser102 for Gly102, is related to female infertility. Design: Screening of fertile and infertile women for the G1502 to A1502 mutation in the LH β-subunit gene. Setting: Clinics and laboratories of the National University Hospital obstetrics and gynecology department, Singapore. Patient(s): Two hundred twelve healthy fertile women; 40 infertile women with menstrual disorders, polycystic ovary syndrome, and endometriosis; and 12 women with idiopathic infertility. Intervention(s): Exon 3 of the LH β-subunit gene was analyzed using polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), and PCR-mediated direct DNA sequencing. Main Outcome Measure(s): The PCR products of patients were analyzed by RFLP, and the results were compared with those of fertile controls. DNA sequencing radiographs were compared between two mutation-bearing patients and four controls. Result(s): The mutation was identified in only two infertile women with endometriosis; other women studied were found to be negative for this mutation. Conclusion(s): The missense mutation in the LH β-subunit gene may be implicated in female infertility, possibly endometriosis-associated infertility in some women. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0015-0282(97)00445-7 | |
dc.source | Scopus | |
dc.subject | Endometriosis | |
dc.subject | Female infertility | |
dc.subject | LH β-subunit | |
dc.subject | Missense mutation | |
dc.subject | PCR | |
dc.subject | RFLP | |
dc.type | Article | |
dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
dc.description.doi | 10.1016/S0015-0282(97)00445-7 | |
dc.description.sourcetitle | Fertility and Sterility | |
dc.description.volume | 69 | |
dc.description.issue | 1 | |
dc.description.page | 102-106 | |
dc.description.coden | FESTA | |
dc.identifier.isiut | 000071673300020 | |
Appears in Collections: | Staff Publications |
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