Please use this identifier to cite or link to this item:
|Title:||Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2methyl ester||Authors:||Adaikan, P.G.
|Issue Date:||1990||Citation:||Adaikan, P.G., Lau, L.C., Chua, Y.T., Ratnam, S.S. (1990). Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2methyl ester. Prostaglandins Leukotrienes and Essential Fatty Acids 39 (1) : 91-94. ScholarBank@NUS Repository. https://doi.org/10.1016/0952-3278(90)90179-O||Abstract:||The biological activity and anti-prostaglandin property of the prostaglandin analoque, ent-11-epi-15-epi PGE2 methyl ester, were studied on isolated guinea pig ileum. Ent-11-epi-15-epi PGE2 methyl ester contracted guinea pig ileum and produced a concentration-response curve parallel to that of PGE2. However, the former exhibited a lower maximal effect than PGE2. At concentrations > 10-6M, ent-11-epi-15-epi PGE2 methyl ester selectively antagonized contractile actions of PGE2 and PGE(2α) without affecting contractions induced by acetylcholine. These observations suggest that the PG analogue acted like a competitive antagonist to PGE2 and PGF(2α) on guinea pig ileum in vitro.||Source Title:||Prostaglandins Leukotrienes and Essential Fatty Acids||URI:||http://scholarbank.nus.edu.sg/handle/10635/36912||ISSN:||09523278||DOI:||10.1016/0952-3278(90)90179-O|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 14, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.