Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2methyl ester

Please use this identifier to cite or link to this item: https://doi.org/10.1016/0952-3278(90)90179-O

Title:	Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2methyl ester
Authors:	Adaikan, P.G. Lau, L.C. Chua, Y.T. Ratnam, S.S.
Issue Date:	Jan-1990
Citation:	Adaikan, P.G., Lau, L.C., Chua, Y.T., Ratnam, S.S. (1990-01). Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2methyl ester. Prostaglandins, Leukotrienes and Essential Fatty Acids 39 (1) : 91-94. ScholarBank@NUS Repository. https://doi.org/10.1016/0952-3278(90)90179-O
Abstract:	The biological activity and anti-prostaglandin property of the prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester, were studied on isolated guinea pig ileum. Ent-11-epi-15-epi PGE2 methyl ester contracted guinea pig ileum and produced a concentration-response curve parallel to that of PGE2. However, the former exhibited a lower maximal effect than PGE2. At concentrations > 10-6M, ent-11-epi-15-epi PGE2 methyl ester selectively antagonized contractile actions of PGE2 and PGE2α without affecting contractions induced by acetylcholine. These observations suggest that the PG analogue acted like a competitive antagonist to PGE2 and PGF2α on guinea pig ileum in vitro. © 1990.
Source Title:	Prostaglandins, Leukotrienes and Essential Fatty Acids
URI:	http://scholarbank.nus.edu.sg/handle/10635/36912
ISSN:	09523278
DOI:	10.1016/0952-3278(90)90179-O
Appears in Collections:	Staff Publications

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