Please use this identifier to cite or link to this item:
https://doi.org/10.1016/0952-3278(90)90179-O
| DC Field | Value | |
|---|---|---|
| dc.title | Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2methyl ester | |
| dc.contributor.author | Adaikan, P.G. | |
| dc.contributor.author | Lau, L.C. | |
| dc.contributor.author | Chua, Y.T. | |
| dc.contributor.author | Ratnam, S.S. | |
| dc.date.accessioned | 2013-04-10T02:58:42Z | |
| dc.date.available | 2013-04-10T02:58:42Z | |
| dc.date.issued | 1990-01 | |
| dc.identifier.citation | Adaikan, P.G., Lau, L.C., Chua, Y.T., Ratnam, S.S. (1990-01). Biological activity and anti-prostaglandin effects of prostaglandin analogue, ent-11-epi-15-epi PGE2methyl ester. Prostaglandins, Leukotrienes and Essential Fatty Acids 39 (1) : 91-94. ScholarBank@NUS Repository. https://doi.org/10.1016/0952-3278(90)90179-O | |
| dc.identifier.issn | 09523278 | |
| dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/36912 | |
| dc.description.abstract | The biological activity and anti-prostaglandin property of the prostaglandin analogue, ent-11-epi-15-epi PGE2 methyl ester, were studied on isolated guinea pig ileum. Ent-11-epi-15-epi PGE2 methyl ester contracted guinea pig ileum and produced a concentration-response curve parallel to that of PGE2. However, the former exhibited a lower maximal effect than PGE2. At concentrations > 10-6M, ent-11-epi-15-epi PGE2 methyl ester selectively antagonized contractile actions of PGE2 and PGE2α without affecting contractions induced by acetylcholine. These observations suggest that the PG analogue acted like a competitive antagonist to PGE2 and PGF2α on guinea pig ileum in vitro. © 1990. | |
| dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/0952-3278(90)90179-O | |
| dc.source | Scopus | |
| dc.type | Article | |
| dc.contributor.department | OBSTETRICS & GYNAECOLOGY | |
| dc.description.doi | 10.1016/0952-3278(90)90179-O | |
| dc.description.sourcetitle | Prostaglandins, Leukotrienes and Essential Fatty Acids | |
| dc.description.volume | 39 | |
| dc.description.issue | 1 | |
| dc.description.page | 91-94 | |
| dc.description.coden | PLEAE | |
| dc.identifier.isiut | A1990CQ43100016 | |
| Appears in Collections: | Staff Publications | |
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