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https://doi.org/10.1016/S0092-8674(03)00810-9
Title: | F3/contactin acts as a functional ligand for notch during oligodendrocyte maturation | Authors: | Hu, Q.-D. Ang, B.-T. Cui, X.-Y. Duka, T. Chia, W. Xiao, Z.-C. Ng, Y.-K. Ling, E.-A. Karsak, M. Schachner, M. Hu, W.-P. Takeda, Y. Watanabe, K. Sankar, N. Maciag, T. Small, D. Trifonova, R. Kopan, R. Okano, H. Nakafuku, M. Chiba, S. Hirai, H. Aster, J.C. Pallen, C.J. |
Issue Date: | 2003 | Citation: | Hu, Q.-D., Ang, B.-T., Cui, X.-Y., Duka, T., Chia, W., Xiao, Z.-C., Ng, Y.-K., Ling, E.-A., Karsak, M., Schachner, M., Hu, W.-P., Takeda, Y., Watanabe, K., Sankar, N., Maciag, T., Small, D., Trifonova, R., Kopan, R., Okano, H., Nakafuku, M., Chiba, S., Hirai, H., Aster, J.C., Pallen, C.J. (2003). F3/contactin acts as a functional ligand for notch during oligodendrocyte maturation. Cell 115 (2) : 163-175. ScholarBank@NUS Repository. https://doi.org/10.1016/S0092-8674(03)00810-9 | Abstract: | Axon-derived molecules are temporally and spatially required as positive or negative signals to coordinate oligodendrocyte differentiation. Increasing evidence suggests that, in addition to the inhibitory Jagged1/Notch1 signaling cascade, other pathways act via Notch to mediate oligodendrocyte differentiation. The GPI-linked neural cell recognition molecule F3/contactin is clustered during development at the paranodal region, a vital site for axoglial interaction. Here, we show that F3/contactin acts as a functional ligand of Notch. This trans-extracellular interaction triggers γ-secretase-dependent nuclear translocation of the Notch intracellular domain. F3/Notch signaling promotes oligodendrocyte precursor cell differentiation and upregulates the myelin-related protein MAG in OLN-93 cells. This can be blocked by dominant negative Notch1, Notch2, and two Deltex1 mutants lacking the RING-H2 finger motif, but not by dominant-negative RBP-J or Hes1 antisense oligonucleotides. Expression of constitutively active Notch1 or Notch2 does not upregulate MAG. Thus, F3/contactin specifically initiates a Notch/Deltex1 signaling pathway that promotes oligodendrocyte maturation and myelination. | Source Title: | Cell | URI: | http://scholarbank.nus.edu.sg/handle/10635/33543 | ISSN: | 00928674 | DOI: | 10.1016/S0092-8674(03)00810-9 |
Appears in Collections: | Staff Publications |
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