Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0092-8674(03)00810-9
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dc.titleF3/contactin acts as a functional ligand for notch during oligodendrocyte maturation
dc.contributor.authorHu, Q.-D.
dc.contributor.authorAng, B.-T.
dc.contributor.authorCui, X.-Y.
dc.contributor.authorDuka, T.
dc.contributor.authorChia, W.
dc.contributor.authorXiao, Z.-C.
dc.contributor.authorNg, Y.-K.
dc.contributor.authorLing, E.-A.
dc.contributor.authorKarsak, M.
dc.contributor.authorSchachner, M.
dc.contributor.authorHu, W.-P.
dc.contributor.authorTakeda, Y.
dc.contributor.authorWatanabe, K.
dc.contributor.authorSankar, N.
dc.contributor.authorMaciag, T.
dc.contributor.authorSmall, D.
dc.contributor.authorTrifonova, R.
dc.contributor.authorKopan, R.
dc.contributor.authorOkano, H.
dc.contributor.authorNakafuku, M.
dc.contributor.authorChiba, S.
dc.contributor.authorHirai, H.
dc.contributor.authorAster, J.C.
dc.contributor.authorPallen, C.J.
dc.date.accessioned2012-06-08T09:23:15Z
dc.date.available2012-06-08T09:23:15Z
dc.date.issued2003
dc.identifier.citationHu, Q.-D., Ang, B.-T., Cui, X.-Y., Duka, T., Chia, W., Xiao, Z.-C., Ng, Y.-K., Ling, E.-A., Karsak, M., Schachner, M., Hu, W.-P., Takeda, Y., Watanabe, K., Sankar, N., Maciag, T., Small, D., Trifonova, R., Kopan, R., Okano, H., Nakafuku, M., Chiba, S., Hirai, H., Aster, J.C., Pallen, C.J. (2003). F3/contactin acts as a functional ligand for notch during oligodendrocyte maturation. Cell 115 (2) : 163-175. ScholarBank@NUS Repository. https://doi.org/10.1016/S0092-8674(03)00810-9
dc.identifier.issn00928674
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/33543
dc.description.abstractAxon-derived molecules are temporally and spatially required as positive or negative signals to coordinate oligodendrocyte differentiation. Increasing evidence suggests that, in addition to the inhibitory Jagged1/Notch1 signaling cascade, other pathways act via Notch to mediate oligodendrocyte differentiation. The GPI-linked neural cell recognition molecule F3/contactin is clustered during development at the paranodal region, a vital site for axoglial interaction. Here, we show that F3/contactin acts as a functional ligand of Notch. This trans-extracellular interaction triggers γ-secretase-dependent nuclear translocation of the Notch intracellular domain. F3/Notch signaling promotes oligodendrocyte precursor cell differentiation and upregulates the myelin-related protein MAG in OLN-93 cells. This can be blocked by dominant negative Notch1, Notch2, and two Deltex1 mutants lacking the RING-H2 finger motif, but not by dominant-negative RBP-J or Hes1 antisense oligonucleotides. Expression of constitutively active Notch1 or Notch2 does not upregulate MAG. Thus, F3/contactin specifically initiates a Notch/Deltex1 signaling pathway that promotes oligodendrocyte maturation and myelination.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0092-8674(03)00810-9
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.doi10.1016/S0092-8674(03)00810-9
dc.description.sourcetitleCell
dc.description.volume115
dc.description.issue2
dc.description.page163-175
dc.description.codenCELLB
dc.identifier.isiut000186039200008
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