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Title: Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction
Authors: Sun, J.
Tan, B.K.-H.
Zhu, Y.Z. 
Huang, S.H. 
Whiteman, M. 
Duan, W. 
Zhu, Y.C.
Wu, Y.J.
Ng, Y.
Keywords: Antioxidant
Infarct size
Myocardial infarction
Purified Salvia miltiorrhiza extract (PSME)
Salvia miltiorrhiza
Issue Date: 2005
Publisher: Elsevier
Citation: Sun, J., Tan, B.K.-H., Zhu, Y.Z., Huang, S.H., Whiteman, M., Duan, W., Zhu, Y.C., Wu, Y.J., Ng, Y. (2005). Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction. Life Sciences 76 (24) : 2849-2860. ScholarBank@NUS Repository.
Abstract: In the current study, we compared purified Salvia miltiorrhiza extract (PSME) with Angiotensin-converting enzyme inhibitor, Ramipril, in in vitro experiments and also in vivo using animal model of myocardial infarction. PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free radicals. PSME could also prevent pyrogallo red bleaching and DNA damage. After 2 weeks treatment with PSME or Ramipril, survival rates of rats with experimental myocardial infarction were marginally increased (68.2% and 71.4%) compared with saline (61.5%). The ratios of infarct size to left ventricular size in both PSME-and Ramipril-treated rats were significantly less than that in the saline-treated group. Activity of cardiac antioxidant enzyme superoxide dismutase (SOD) was significant higher while level of Thiobarbituric acid-reactive substances (TBARs) was lower in the PSME treated group. Purified and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease. © 2005 Elsevier Inc. All rights reserved.
Source Title: Life Sciences
ISSN: 00243205
DOI: 10.1016/j.lfs.2004.11.016
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