Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.lfs.2004.11.016
DC Field | Value | |
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dc.title | Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction | |
dc.contributor.author | Sun, J. | |
dc.contributor.author | Tan, B.K.-H. | |
dc.contributor.author | Zhu, Y.Z. | |
dc.contributor.author | Huang, S.H. | |
dc.contributor.author | Whiteman, M. | |
dc.contributor.author | Duan, W. | |
dc.contributor.author | Zhu, Y.C. | |
dc.contributor.author | Wu, Y.J. | |
dc.contributor.author | Ng, Y. | |
dc.date.accessioned | 2012-04-02T07:54:54Z | |
dc.date.available | 2012-04-02T07:54:54Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Sun, J., Tan, B.K.-H., Zhu, Y.Z., Huang, S.H., Whiteman, M., Duan, W., Zhu, Y.C., Wu, Y.J., Ng, Y. (2005). Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction. Life Sciences 76 (24) : 2849-2860. ScholarBank@NUS Repository. https://doi.org/10.1016/j.lfs.2004.11.016 | |
dc.identifier.issn | 00243205 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/32263 | |
dc.description.abstract | In the current study, we compared purified Salvia miltiorrhiza extract (PSME) with Angiotensin-converting enzyme inhibitor, Ramipril, in in vitro experiments and also in vivo using animal model of myocardial infarction. PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free radicals. PSME could also prevent pyrogallo red bleaching and DNA damage. After 2 weeks treatment with PSME or Ramipril, survival rates of rats with experimental myocardial infarction were marginally increased (68.2% and 71.4%) compared with saline (61.5%). The ratios of infarct size to left ventricular size in both PSME-and Ramipril-treated rats were significantly less than that in the saline-treated group. Activity of cardiac antioxidant enzyme superoxide dismutase (SOD) was significant higher while level of Thiobarbituric acid-reactive substances (TBARs) was lower in the PSME treated group. Purified and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease. © 2005 Elsevier Inc. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.lfs.2004.11.016 | |
dc.publisher | Elsevier | |
dc.source | Scopus | |
dc.subject | Antioxidant | |
dc.subject | Infarct size | |
dc.subject | Myocardial infarction | |
dc.subject | Purified Salvia miltiorrhiza extract (PSME) | |
dc.subject | Ramipril | |
dc.subject | Salvia miltiorrhiza | |
dc.type | Article | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.department | PHARMACOLOGY | |
dc.description.doi | 10.1016/j.lfs.2004.11.016 | |
dc.description.sourcetitle | Life Sciences | |
dc.description.volume | 76 | |
dc.description.issue | 24 | |
dc.description.page | 2849-2860 | |
dc.description.coden | LIFSA | |
dc.identifier.isiut | 000228380900008 | |
Appears in Collections: | Staff Publications |
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