Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.lfs.2004.11.016
DC FieldValue
dc.titleEffects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction
dc.contributor.authorSun, J.
dc.contributor.authorTan, B.K.-H.
dc.contributor.authorZhu, Y.Z.
dc.contributor.authorHuang, S.H.
dc.contributor.authorWhiteman, M.
dc.contributor.authorDuan, W.
dc.contributor.authorZhu, Y.C.
dc.contributor.authorWu, Y.J.
dc.contributor.authorNg, Y.
dc.date.accessioned2012-04-02T07:54:54Z
dc.date.available2012-04-02T07:54:54Z
dc.date.issued2005
dc.identifier.citationSun, J., Tan, B.K.-H., Zhu, Y.Z., Huang, S.H., Whiteman, M., Duan, W., Zhu, Y.C., Wu, Y.J., Ng, Y. (2005). Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction. Life Sciences 76 (24) : 2849-2860. ScholarBank@NUS Repository. https://doi.org/10.1016/j.lfs.2004.11.016
dc.identifier.issn00243205
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/32263
dc.description.abstractIn the current study, we compared purified Salvia miltiorrhiza extract (PSME) with Angiotensin-converting enzyme inhibitor, Ramipril, in in vitro experiments and also in vivo using animal model of myocardial infarction. PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free radicals. PSME could also prevent pyrogallo red bleaching and DNA damage. After 2 weeks treatment with PSME or Ramipril, survival rates of rats with experimental myocardial infarction were marginally increased (68.2% and 71.4%) compared with saline (61.5%). The ratios of infarct size to left ventricular size in both PSME-and Ramipril-treated rats were significantly less than that in the saline-treated group. Activity of cardiac antioxidant enzyme superoxide dismutase (SOD) was significant higher while level of Thiobarbituric acid-reactive substances (TBARs) was lower in the PSME treated group. Purified and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease. © 2005 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.lfs.2004.11.016
dc.publisherElsevier
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectInfarct size
dc.subjectMyocardial infarction
dc.subjectPurified Salvia miltiorrhiza extract (PSME)
dc.subjectRamipril
dc.subjectSalvia miltiorrhiza
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.lfs.2004.11.016
dc.description.sourcetitleLife Sciences
dc.description.volume76
dc.description.issue24
dc.description.page2849-2860
dc.description.codenLIFSA
dc.identifier.isiut000228380900008
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.