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Title: Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts
Authors: Sun, J.
Tan, B.K.-H.
Zhu, Y.Z. 
Huang, S.H. 
Whiteman, M. 
Zhu, Y.C.
Wang, M.J.
Keywords: Glutathione peroxidase
Herba leonur
Lipid peroxidation
Myocardial infarction
Oxidative stress
Superoxide dismutase
Issue Date: 2005
Citation: Sun, J., Tan, B.K.-H., Zhu, Y.Z., Huang, S.H., Whiteman, M., Zhu, Y.C., Wang, M.J. (2005). Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts. Life Sciences 76 (26) : 3043-3056. ScholarBank@NUS Repository.
Abstract: Our current study was to test the hypothesis that the extract of Herba leonuri (HL) would have antioxidant and cardioprotective effects on ischemic myocardium. The extract of HL (400 mg/kg/day) was administered orally (daily) starting from 1 week before and continuing until 3 weeks after myocardial infarction (MI). Surviving rats were sacrificed at different time points to obtain left ventricles for biochemical assays. Our study demonstrates for the first time that HL does have antioxidant effects both in vitro and in vivo. The antioxidant effects of HL are exerted only under the condition of oxidative stress, by selectively preserving the activities of superoxide dismutase and glutathione peroxidase, as well as depressing the formation of malondialdehyde, especially in the acute phase of acute MI. Its effects of scavenging free radicals and inhibiting the formation of reactive oxygen species may play a key role in protecting the endogenous antioxidant system from oxidative stress in vivo. © 2005 Elsevier Inc. All rights reserved.
Source Title: Life Sciences
ISSN: 00243205
DOI: 10.1016/j.lfs.2004.11.024
Appears in Collections:Staff Publications

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