Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.lfs.2004.11.024
DC FieldValue
dc.titleAnti-oxidative stress effects of Herba leonuri on ischemic rat hearts
dc.contributor.authorSun, J.
dc.contributor.authorTan, B.K.-H.
dc.contributor.authorZhu, Y.Z.
dc.contributor.authorHuang, S.H.
dc.contributor.authorWhiteman, M.
dc.contributor.authorZhu, Y.C.
dc.contributor.authorWang, M.J.
dc.date.accessioned2012-04-02T07:54:45Z
dc.date.available2012-04-02T07:54:45Z
dc.date.issued2005
dc.identifier.citationSun, J., Tan, B.K.-H., Zhu, Y.Z., Huang, S.H., Whiteman, M., Zhu, Y.C., Wang, M.J. (2005). Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts. Life Sciences 76 (26) : 3043-3056. ScholarBank@NUS Repository. https://doi.org/10.1016/j.lfs.2004.11.024
dc.identifier.issn00243205
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/32255
dc.description.abstractOur current study was to test the hypothesis that the extract of Herba leonuri (HL) would have antioxidant and cardioprotective effects on ischemic myocardium. The extract of HL (400 mg/kg/day) was administered orally (daily) starting from 1 week before and continuing until 3 weeks after myocardial infarction (MI). Surviving rats were sacrificed at different time points to obtain left ventricles for biochemical assays. Our study demonstrates for the first time that HL does have antioxidant effects both in vitro and in vivo. The antioxidant effects of HL are exerted only under the condition of oxidative stress, by selectively preserving the activities of superoxide dismutase and glutathione peroxidase, as well as depressing the formation of malondialdehyde, especially in the acute phase of acute MI. Its effects of scavenging free radicals and inhibiting the formation of reactive oxygen species may play a key role in protecting the endogenous antioxidant system from oxidative stress in vivo. © 2005 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.lfs.2004.11.024
dc.sourceScopus
dc.subjectGlutathione peroxidase
dc.subjectHerba leonur
dc.subjectLipid peroxidation
dc.subjectMyocardial infarction
dc.subjectOxidative stress
dc.subjectSuperoxide dismutase
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.lfs.2004.11.024
dc.description.sourcetitleLife Sciences
dc.description.volume76
dc.description.issue26
dc.description.page3043-3056
dc.description.codenLIFSA
dc.identifier.isiut000228882600004
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