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|Title:||Hepatic expression of PPARα, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner||Authors:||Tai, E.S.
Bin, Ali A.
El, Oakley R.M.
Peroxisome proliferator-activated receptor α
|Issue Date:||2003||Citation:||Tai, E.S., Loh, L.M., Tan, C.E., Bin, Ali A., Zhang, Q., Lim, S.-K., Retnam, L., El, Oakley R.M. (2003). Hepatic expression of PPARα, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner. FEBS Letters 546 (2-3) : 237-240. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(03)00578-7||Abstract:||Dyslipidemia, inflammation and gender are major risk factors in cardiovascular disease. Here we show that hepatic expression of Peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor that regulates lipid metabolism and inflammation, is regulated in a gender-specific manner during lipopolysaccharide (LPS)-induced systemic inflammation. Immediately following LPS-induced systemic inflammation, hepatic PPARα mRNA level decreased dramatically in mice. It was restored to baseline within 24 h in females but remained below baseline for >72 h in male mice. In gonadectomized mice of both sexes, PPARα mRNA level was restored to baseline within 48 h after the initial decrease. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.||Source Title:||FEBS Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/29462||ISSN:||00145793||DOI:||10.1016/S0014-5793(03)00578-7|
|Appears in Collections:||Staff Publications|
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