Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0014-5793(03)00578-7
DC Field | Value | |
---|---|---|
dc.title | Hepatic expression of PPARα, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner | |
dc.contributor.author | Tai, E.S. | |
dc.contributor.author | Loh, L.M. | |
dc.contributor.author | Tan, C.E. | |
dc.contributor.author | Bin, Ali A. | |
dc.contributor.author | Zhang, Q. | |
dc.contributor.author | Lim, S.-K. | |
dc.contributor.author | Retnam, L. | |
dc.contributor.author | El, Oakley R.M. | |
dc.date.accessioned | 2011-11-30T06:34:17Z | |
dc.date.available | 2011-11-30T06:34:17Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Tai, E.S., Loh, L.M., Tan, C.E., Bin, Ali A., Zhang, Q., Lim, S.-K., Retnam, L., El, Oakley R.M. (2003). Hepatic expression of PPARα, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner. FEBS Letters 546 (2-3) : 237-240. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-5793(03)00578-7 | |
dc.identifier.issn | 00145793 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/29462 | |
dc.description.abstract | Dyslipidemia, inflammation and gender are major risk factors in cardiovascular disease. Here we show that hepatic expression of Peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor that regulates lipid metabolism and inflammation, is regulated in a gender-specific manner during lipopolysaccharide (LPS)-induced systemic inflammation. Immediately following LPS-induced systemic inflammation, hepatic PPARα mRNA level decreased dramatically in mice. It was restored to baseline within 24 h in females but remained below baseline for >72 h in male mice. In gonadectomized mice of both sexes, PPARα mRNA level was restored to baseline within 48 h after the initial decrease. © 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-5793(03)00578-7 | |
dc.source | Scopus | |
dc.subject | Cardiovascular disease | |
dc.subject | Gender | |
dc.subject | Inflammation | |
dc.subject | mRNA | |
dc.subject | Peroxisome proliferator-activated receptor α | |
dc.type | Article | |
dc.contributor.department | SURGERY | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | CENTRE FOR MOLECULAR EPIDEMIOLOGY | |
dc.contributor.department | PHYSIOLOGY | |
dc.contributor.department | NATIONAL UNIVERSITY MEDICAL INSTITUTES | |
dc.description.doi | 10.1016/S0014-5793(03)00578-7 | |
dc.description.sourcetitle | FEBS Letters | |
dc.description.volume | 546 | |
dc.description.issue | 2-3 | |
dc.description.page | 237-240 | |
dc.description.coden | FEBLA | |
dc.identifier.isiut | 000183964000014 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.