Please use this identifier to cite or link to this item:
|Title:||Oxidative damage in Parkinson disease: Measurement using accurate biomarkers||Authors:||Seet, R.C.S.
|Issue Date:||2010||Citation:||Seet, R.C.S., Lee, C.-Y.J., Lim, E.C.H., Chong, W.-L., Looi, W.-F., Tan, J.J.H., Quek, A.M.L., Huang, S.-H., Wang, H., Halliwell, B., Chan, Y.-H. (2010). Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. Free Radical Biology and Medicine 48 (4) : 560-566. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2009.11.026||Abstract:||Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F2-isoprostanes (F2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F4-NPs), phospholipase A2 (PLA2) and platelet activating factor-acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA2 and PAF-AH activities were lower, in PD patients compared to controls (p < 0.05). The levels of plasma F2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (p trend < 0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (r = -0.305, p = 0.023) and plasma total HETEs (r = -0.285, p = 0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD. © 2009 Elsevier Inc. All rights reserved.||Source Title:||Free Radical Biology and Medicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/28889||ISSN:||08915849||DOI:||10.1016/j.freeradbiomed.2009.11.026|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Apr 15, 2019
WEB OF SCIENCETM
checked on Apr 8, 2019
checked on Apr 21, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.