Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2009.11.026
Title: Oxidative damage in Parkinson disease: Measurement using accurate biomarkers
Authors: Seet, R.C.S.
Lee, C.-Y.J.
Lim, E.C.H.
Chong, W.-L.
Looi, W.-F. 
Tan, J.J.H.
Quek, A.M.L.
Huang, S.-H. 
Wang, H. 
Halliwell, B. 
Chan, Y.-H.
Keywords: 8-Hydroxy-2′-deoxyguanosine
F2-isoprostanes
Free radicals
Neuroprostanes
Oxidative stress
Parkinson disease
Issue Date: 2010
Source: Seet, R.C.S., Lee, C.-Y.J., Lim, E.C.H., Chong, W.-L., Looi, W.-F., Tan, J.J.H., Quek, A.M.L., Huang, S.-H., Wang, H., Halliwell, B., Chan, Y.-H. (2010). Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. Free Radical Biology and Medicine 48 (4) : 560-566. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2009.11.026
Abstract: Oxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F2-isoprostanes (F2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F4-NPs), phospholipase A2 (PLA2) and platelet activating factor-acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA2 and PAF-AH activities were lower, in PD patients compared to controls (p < 0.05). The levels of plasma F2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (p trend < 0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (r = -0.305, p = 0.023) and plasma total HETEs (r = -0.285, p = 0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD. © 2009 Elsevier Inc. All rights reserved.
Source Title: Free Radical Biology and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/28889
ISSN: 08915849
DOI: 10.1016/j.freeradbiomed.2009.11.026
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

119
checked on Dec 5, 2017

WEB OF SCIENCETM
Citations

106
checked on Nov 16, 2017

Page view(s)

181
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.