Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.freeradbiomed.2009.11.026
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dc.titleOxidative damage in Parkinson disease: Measurement using accurate biomarkers
dc.contributor.authorSeet, R.C.S.
dc.contributor.authorLee, C.-Y.J.
dc.contributor.authorLim, E.C.H.
dc.contributor.authorChong, W.-L.
dc.contributor.authorLooi, W.-F.
dc.contributor.authorTan, J.J.H.
dc.contributor.authorQuek, A.M.L.
dc.contributor.authorHuang, S.-H.
dc.contributor.authorWang, H.
dc.contributor.authorHalliwell, B.
dc.contributor.authorChan, Y.-H.
dc.date.accessioned2011-11-29T06:10:39Z
dc.date.available2011-11-29T06:10:39Z
dc.date.issued2010
dc.identifier.citationSeet, R.C.S., Lee, C.-Y.J., Lim, E.C.H., Chong, W.-L., Looi, W.-F., Tan, J.J.H., Quek, A.M.L., Huang, S.-H., Wang, H., Halliwell, B., Chan, Y.-H. (2010). Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. Free Radical Biology and Medicine 48 (4) : 560-566. ScholarBank@NUS Repository. https://doi.org/10.1016/j.freeradbiomed.2009.11.026
dc.identifier.issn08915849
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/28889
dc.description.abstractOxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F2-isoprostanes (F2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F4-NPs), phospholipase A2 (PLA2) and platelet activating factor-acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA2 and PAF-AH activities were lower, in PD patients compared to controls (p < 0.05). The levels of plasma F2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (p trend < 0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (r = -0.305, p = 0.023) and plasma total HETEs (r = -0.285, p = 0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD. © 2009 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.freeradbiomed.2009.11.026
dc.sourceScopus
dc.subject8-Hydroxy-2′-deoxyguanosine
dc.subjectF2-isoprostanes
dc.subjectFree radicals
dc.subjectNeuroprostanes
dc.subjectOxidative stress
dc.subjectParkinson disease
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentMEDICINE
dc.description.doi10.1016/j.freeradbiomed.2009.11.026
dc.description.sourcetitleFree Radical Biology and Medicine
dc.description.volume48
dc.description.issue4
dc.description.page560-566
dc.description.codenFRBME
dc.identifier.isiut000274235500011
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