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https://doi.org/10.1016/j.febslet.2008.06.046
Title: | Role of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells | Authors: | Yamamura, Y. Lee, W.L. Goh, M.X. Ito, Y. |
Keywords: | Apoptosis Gastric cancer p73 TGF-β |
Issue Date: | 2008 | Citation: | Yamamura, Y., Lee, W.L., Goh, M.X., Ito, Y. (2008). Role of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells. FEBS Letters 582 (17) : 2663-2667. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2008.06.046 | Abstract: | Transforming growth factor-β (TGF-β) is implicated as a tumor suppressor because it eliminates cancer cells from normal tissues by inhibiting cell growth and inducing apoptosis. Although p53 tumor suppressor is required for TGF-β-induced p21WAF1 expression and cell growth inhibition, its role in TGF-β-induced apoptosis remains unclear. Here, we report that TAp73α, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic Bax and Puma to activate their transcription, and mediates TGF-β-induced apoptosis in gastric cancer cells. Our findings reveal a novel role of TAp73α in the induction of apoptosis by TGF-β in cancer cells. © 2008 Federation of European Biochemical Societies. | Source Title: | FEBS Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/27092 | ISSN: | 00145793 | DOI: | 10.1016/j.febslet.2008.06.046 |
Appears in Collections: | Staff Publications |
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