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|Title:||Role of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells|
|Authors:||Yamamura, Y. |
|Citation:||Yamamura, Y., Lee, W.L., Goh, M.X., Ito, Y. (2008). Role of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells. FEBS Letters 582 (17) : 2663-2667. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2008.06.046|
|Abstract:||Transforming growth factor-β (TGF-β) is implicated as a tumor suppressor because it eliminates cancer cells from normal tissues by inhibiting cell growth and inducing apoptosis. Although p53 tumor suppressor is required for TGF-β-induced p21WAF1 expression and cell growth inhibition, its role in TGF-β-induced apoptosis remains unclear. Here, we report that TAp73α, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic Bax and Puma to activate their transcription, and mediates TGF-β-induced apoptosis in gastric cancer cells. Our findings reveal a novel role of TAp73α in the induction of apoptosis by TGF-β in cancer cells. © 2008 Federation of European Biochemical Societies.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
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