Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2008.06.046
Title: Role of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells
Authors: Yamamura, Y. 
Lee, W.L.
Goh, M.X.
Ito, Y. 
Keywords: Apoptosis
Gastric cancer
p73
TGF-β
Issue Date: 2008
Source: Yamamura, Y., Lee, W.L., Goh, M.X., Ito, Y. (2008). Role of TAp73α in induction of apoptosis by transforming growth factor-β in gastric cancer cells. FEBS Letters 582 (17) : 2663-2667. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2008.06.046
Abstract: Transforming growth factor-β (TGF-β) is implicated as a tumor suppressor because it eliminates cancer cells from normal tissues by inhibiting cell growth and inducing apoptosis. Although p53 tumor suppressor is required for TGF-β-induced p21WAF1 expression and cell growth inhibition, its role in TGF-β-induced apoptosis remains unclear. Here, we report that TAp73α, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic Bax and Puma to activate their transcription, and mediates TGF-β-induced apoptosis in gastric cancer cells. Our findings reveal a novel role of TAp73α in the induction of apoptosis by TGF-β in cancer cells. © 2008 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/27092
ISSN: 00145793
DOI: 10.1016/j.febslet.2008.06.046
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